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Introducing February Guest Blogger: Dr. Malcolm Moore

Thank you to our January guest blogger, Dr. Steven Jones, who shared so personally how his curiosity of genetics while growing up on a sheep farm in Wales fueled his passion, leading to a career in bioinformatics. This month, we’re excited to welcome Dr. Malcolm Moore, President of the BC Cancer Agency. Dr. Moore joined the Agency last fall, and he’ll share how a chance appointment with a doctor led him to trade in his accounting books for a stethoscope and pursue a career in medicine. Passionate about quality cancer care he will also share his insight and vision for the future of cancer care...

Looking Ahead

We are living in an exciting time—where cancer is being forced to reveal its genetic tricks and give up the molecular underpinnings it has been secretly using to grow within our bodies and evade our drugs. Couple these insights from sixty years of basic science charting and painstakingly determining the roles that genes and proteins normally play in our cells, and we have an unprecedented view of how cancer cells are working against us. We also now have the DNA sequencing tools in place to determine the combination of molecular changes that drive the growth of a particular patient’s tumour at...

A Petabase: no ordinary number

As Head of Bioinformatics at the Genome Sciences Centre, my role is to oversee the computational analysis of the DNA sequence data that we are generating. While sequencing technologies can now rapidly produce copious amounts of raw DNA sequence, computational challenges remain. Currently, we have over nine petabytes of disk space – that’s nine million gigabytes, or the equivalent space on more than 70,300 of the best iPads. And there are over 8,000 CPUs churning away 24/7 analyzing these sequences. Detective Work The human genome contains around three billion base pairs of DNA sequence...

Coming to British Columbia

During the tail end of my PhD in Cambridge, I was contacted by Dr Michael Smith from the University of British Columbia. He explained he was interested in visiting the Sanger Institute , in the UK. Obviously, I was fully aware of the famous Dr Smith—British Columbia's home grown Nobel Prize winner. Although, to this day, I am not one hundred percent clear why he contacted me, I was nonetheless delighted to show him around the Sanger Institute. At that time the Institute was bursting at the seams with DNA sequencing activity for the human genome project. It must have been even more fascinating...

The Wondering Years

I grew up on a sheep farm in Wales, near a small town called Lampeter. My favorite subject at school was biology and I was lucky to have very engaged and passionate teachers in that subject that fueled my interest further. Similarly on the farm, I was always fascinated and intrigued by the selective breeding that had gone on to create the diversity of agricultural breeds, not only differing in their physical appearance but also in their temperaments and behaviour. Image: www.upsplash.com On being inspired This led me to do an undergraduate degree in Biochemistry at the University of Bristol,...

Introducing January Guest Blogger: Dr. Steven Jones

Thank you to our December guest blogger, Dr. Howard Lim, who shared how his passion for science as a child led to a career treating people with cancer and doing research on this challenging and complex disease. This month, we’re excited to welcome Dr. Steven Jones, the Head of Bioinformatics and Associate Director at the Michael Smith Genome Sciences Centre. Dr. Jones is a detective, though not of the crime fighting type you might think. Instead of a tweed hat and Sherlock Holmes-like magnifying glass, Dr. Jones and his team have high tech machines and use robotics to sequence cancer. This...

Reflections on Today and Tomorrow

As part of the GI Cancer outcomes unit, the research we do ensures that new therapies are achieving the benefits in a cost effective manner. We can also use this data to link to our various pathology tumor banks to explore new areas of understanding of the causes of certain cancers in the hopes of developing new therapies and methods of detection. Our clinical trials units have continued to provide state of the art treatment for oncology patients that are not yet approved. The use of sequencing technology has helped us understand tumor biology better and hopefully in the future will provide...

Spirit of Giving

As this is the week leading up to Christmas, I would like to wish everyone all the very best over the holiday season. Each year working at the BC Cancer Agency has been a new adventure and I am grateful to work here. Every person who is treated at the Agency has the opportunity to exceed their potential and it is a privilege to experience this every day. It’s also the perfect time of time of year to thank the donors who have been key to research and innovation. These projects directly affect patient care and outcomes. Donor support leads to innovative work The BC Cancer Agency is an...

The Power of Research

I am actively involved in clinical research at the BC Cancer Agency, including being an investigator in several gastrointestinal cancer clinical trials for patients, and as such am fortunate to be able to help with the translation of research into patient outcomes. We have a world class research centre and treatment facility. Some of the research requires access to tissue samples to gain a better understanding of how cancer develops. Other research directly impacts on patient care such as clinical trials or the Personalized Onco-Genomics (POG) Program . To be honest, there is so much going on...

Dr. Howard Lim: Mad-Scientist kid turned cancer researcher

Thanks to the BC Cancer Foundation for inviting me to be a guest blogger! I am a medical oncologist at the BC Cancer Agency Vancouver Centre, specializing in gastrointestinal cancer. I look forward to posting over the holiday season. I grew up in Vancouver, and my interest in science started when I was in elementary school, mainly due to trips to the library where I read books on do-it-yourself science experiments. I blew up potatoes, jumped off the balcony with garbage bags as a parachute, and other mad-scientist type adventures. Prior to going to medical school, I was fortunate to do...

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