Dr. Sohrab Shah
Scientist, Department of Molecular Oncology, BC Cancer Agency; and Assistant Professor, Department of Pathology, UBC

Blog Posts by Dr. Sohrab Shah

Displaying 1 - 5 of 5 blog posts

The time to support cancer research is now

Thank you for reading my posts thus far. I thought I would close with some thoughts on looking forward. It is a particularly exciting time for cancer research and there are many reasons for patients to be optimistic that real progress is being made in our understanding of cancer. A major goal of the BC Cancer Agency is to translate research findings into clinical application. The future directions for my lab are to investigate how clonal diversity in tumours impacts patient outcomes. We will ask questions like: Can the degree of clonal diversity within a patient's tumour predict how a patient...

More progress and the importance of studying breast cancer genomes

In another recent study this year with Dr. Sam Aparicio, and Dr. Carlos Caldas, of Cambridge University, we explored the genomes of breast cancers and my team was responsible for the computational analysis of more than two million genomic measurements for each of 2000 breast cancers. You can read more about study here , it was also published in Nature magazine. We set out to find patterns in the population of breast cancer tumours, and look at other questions like, what genomic patterns are in common? And could they be used to group patients together to help predict clinical behaviour? Using...

Cancer Genome Sequencing and Amazing Progress

The field of cancer genome sequencing has exploded due to amazing early progress in identifying new mutations in cancer, patterns of how tumours change over time and identification of new disease subtypes. The work my team and I have done has contributed to this progress due to innovations in computationally modeling these datasets to infer mutations responsible for disease. Currently my work is focused on analysis of ovarian, breast and lymphoid cancers. There is so much we do not yet understand about the behaviour of these diseases in the context of chemotherapeutic response, progression...

A disease of the genome & Me at the BC Cancer Agency

During my PhD at UBC, I became convinced of a notion that had been known for decades: “cancer is a disease of the genome”. So naturally, to further our understanding of cancer, the genomes of tumours would need to be precisely decoded. Frustratingly, technology did not yet exist to study individual tumours in this way. After all, it took the human genome project billions of dollars, 15 years and 1000s of scientists to sequence a single genome. Remarkably, a sea of change in technology in the past five years has brought sequencing the genomes of individuals within practical reach. We are...

Who is Dr. Sohrab Shah?

Thank you Doug, I’m glad to be joining the roster of guest bloggers here at the BC Cancer Foundation. I’m a fan of the virtual word myself, I enjoy using Twitter ( @sohrabshah ) and I have a blog of my own as well: http://compbio.bccrc.ca/ . I’ll start from the top. I was born and raised in Guelph, Ontario, and studied biology at Queen’s University in Kingston. There, I first learned the principles of evolution (more on this later). Towards the end of that degree I became interested in computers and decided to take a degree in computer science at the University of British Columbia (UBC)...