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Cancer Genome Sequencing and Amazing Progress

The field of cancer genome sequencing has exploded due to amazing early progress in identifying new mutations in cancer, patterns of how tumours change over time and identification of new disease subtypes. The work my team and I have done has contributed to this progress due to innovations in computationally modeling these datasets to infer mutations responsible for disease.

Currently...

A disease of the genome & Me at the BC Cancer Agency

During my PhD at UBC, I became convinced of a notion that had been known for decades: “cancer is a disease of the genome”. So naturally, to further our understanding of cancer, the genomes of tumours would need to be precisely decoded.

Frustratingly, technology did not yet exist to study individual tumours in this way. After all, it took the human genome project billions of dollars, 15...

The Personalized Medicine Project (PMP)

Right now, cancer treatment is predominantly a one-size-fits-all approach. Cancer patients may undergo multiple courses of treatments until the right one for them is found. As you can imagine, this can cause added stress for patients and their families, as well as the pressure of time—which not all patients can afford to lose.

One of the ideas behind personalized medicine is to...

The Future of Genomics: Personalized medicine

It really is a very exciting time to work at the BC Cancer Agency’s Genome Sciences Centre (GSC). We are working with many other research teams, both at the Agency and around the world, to help better understand cancer and to use this advanced knowledge to succeed in treating cancer cells.

In the last 18 months, there have been a number of world-class genome science breakthroughs at...

How technology is helping genomics

As I mentioned in my last post, the amount of DNA in your body is astounding, as is the number of cells, which has been estimated at 100 trillion  When I started in genomics, searching for cancer-causing mutations was a huge and expensive endeavor, and simply could not be done comprehensively.  The tools to understand the structure and function of cancer cell genomes simply did not exist....

What is genomics?

Since genomics can seem complicated, let’s start with the basics so that you understand a bit better what my team does.

Many people are aware that the cells of living organisms contain DNA that encodes the information that their cells need to grow and divide normally.  The term genome refers to the DNA within the cells.  Although most of the genome is similar between individuals,...

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