Genomics

Hello everyone,

In this week’s post I’d like to tell you about some of the areas of research we’re working on to improve our ability to diagnose and treat pancreatic cancer. As many of you are aware, pancreatic cancer is a common and very aggressive cancer, and there are several reasons why we have a difficult time treating it: one issue is that pancreatic cancer often doesn’t cause...

When I first started working in cancer genetics, we used old technologies to indentify genetic alterations in tumours. It was challenging work and we were often left in what felt like a no-man’s land. But the discoveries and disease-specific genetic alterations found then are now recognized world-wide as the drivers of those diseases.

These days, the BC Cancer Agency Genome Sciences...

In another recent study this year with Dr. Sam Aparicio, and Dr. Carlos Caldas, of Cambridge University, we explored the genomes of breast cancers and my team was responsible for the computational analysis of more than two million genomic measurements for each of 2000 breast cancers. You can read more about study...

The field of cancer genome sequencing has exploded due to amazing early progress in identifying new mutations in cancer, patterns of how tumours change over time and identification of new disease subtypes. The work my team and I have done has contributed to this progress due to innovations in computationally modeling these datasets to infer mutations responsible for disease.

Currently...

During my PhD at UBC, I became convinced of a notion that had been known for decades: “cancer is a disease of the genome”. So naturally, to further our understanding of cancer, the genomes of tumours would need to be precisely decoded.

Frustratingly, technology did not yet exist to study individual tumours in this way. After all, it took the human genome project billions of dollars, 15...

Thank you Doug, I’m glad to be joining the roster of guest bloggers here at the BC Cancer Foundation. I’m a fan of the virtual word myself, I enjoy using Twitter (@sohrabshah) and I have a blog of my own as well: http://compbio.bccrc.ca/.

I’ll start from the top. I was born and raised in Guelph, Ontario...

We are in the first year of this two-year project currently; and as you can imagine, a study of this scale is costly. Thankfully, the BC Cancer Foundation is a major partner in this research. Their recent Inspiration Gala raised over $1.5...

Right now, cancer treatment is predominantly a one-size-fits-all approach. Cancer patients may undergo multiple courses of treatments until the right one for them is found. As you can imagine, this can cause added stress for patients and their families, as well as the pressure of time—which not all patients can afford to lose.

One of the ideas behind personalized medicine is to...

It really is a very exciting time to work at the BC Cancer Agency’s Genome Sciences Centre (GSC). We are working with many other research teams, both at the Agency and around the world, to help better understand cancer and to use this advanced knowledge to succeed in treating cancer cells.

In the last 18 months, there have been a number of world-class genome science breakthroughs at...

As I mentioned in my last post, the amount of DNA in your body is astounding, as is the number of cells, which has been estimated at 100 trillion  When I started in genomics, searching for cancer-causing mutations was a huge and expensive endeavor, and simply could not be done comprehensively.  The tools to understand the structure and function of cancer cell genomes simply did not exist....